Anthony Fauci: Remdesivir Has a Significant Effect on Diminishing Recovery Time

RUSH TRANSCRIPT Fauci National ░░░░░░░░ of Allergy and Infectious ░░░░░░░░ which is the institute ░░░░░░░░ direct sponsored called the ░░░░░░░░ Covid treatment trial ACTT ░░░░░░░░ was started in February ░░░░░░░░ of this year It ░░░░░░░░ a randomized placebo controlled ░░░░░░░░ Comparing the Gilead drug ░░░░░░░░ with a placebo It ░░░░░░░░ highly powered with about ░░░░░░░░ 090 plus individuals It ░░░░░░░░ the first truly high ░░░░░░░░ randomized placebo controlled trial ░░░░░░░░ was an international trial ░░░░░░░░ multiple sites not only ░░░░░░░░ the United States but ░░░░░░░░ various countries throughout the ░░░░░░░░ including Germany Denmark Spain ░░░░░░░░ the U K et ░░░░░░░░ The primary end point ░░░░░░░░ the time to recovery ░░░░░░░░ the ability to be ░░░░░░░░ When you have a ░░░░░░░░ like this we have ░░░░░░░░ data and safety monitoring ░░░░░░░░ which looks at the ░░░░░░░░ They are independent so ░░░░░░░░ is no prejudice on ░░░░░░░░ part of the investigators ░░░░░░░░ they re doing the ░░░░░░░░ or the drug is ░░░░░░░░ a certain company The ░░░░░░░░ and safety monitoring board ░░░░░░░░ Monday afternoon contacted me ░░░░░░░░ April 27th First on ░░░░░░░░ the week before and ░░░░░░░░ again on April 27th ░░░░░░░░ notified the study team ░░░░░░░░ the multiple investigators doing ░░░░░░░░ study throughout the world ░░░░░░░░ the data shows that ░░░░░░░░ has a clear cut ░░░░░░░░ positive effect in diminishing ░░░░░░░░ time to recovery This ░░░░░░░░ really quite important for ░░░░░░░░ number of reasons I ░░░░░░░░ give you the data ░░░░░░░░ s highly significant If ░░░░░░░░ look at the time ░░░░░░░░ recovery being shorter in ░░░░░░░░ remdesivir arm it was ░░░░░░░░ days compared to 15 ░░░░░░░░ That is a p ░░░░░░░░ for the scientists who ░░░░░░░░ listening of 0 001 ░░░░░░░░ that is something although ░░░░░░░░ 31 in improvement doesn ░░░░░░░░ seem like a knock ░░░░░░░░ 100 it s a ░░░░░░░░ important proof of concept ░░░░░░░░ what it has proven ░░░░░░░░ that a drug can ░░░░░░░░ this virus I will ░░░░░░░░ you an example in ░░░░░░░░ moment of why we ░░░░░░░░ looking forward this is ░░░░░░░░ optimistic The mortality rate ░░░░░░░░ toward being better in ░░░░░░░░ sense of less deaths ░░░░░░░░ the remdesivir group 8 ░░░░░░░░ 11 in the placebo ░░░░░░░░ It has not yet ░░░░░░░░ statistical significance but the ░░░░░░░░ needs to be further ░░░░░░░░ The reason why we ░░░░░░░░ making the announcement now ░░░░░░░░ something that I believe ░░░░░░░░ don t fully appreciate ░░░░░░░░ you have clear cut ░░░░░░░░ that a drug works ░░░░░░░░ have an ethical obligation ░░░░░░░░ immediately let the people ░░░░░░░░ are in the placebo ░░░░░░░░ know so they can ░░░░░░░░ access All of the ░░░░░░░░ trials that are taking ░░░░░░░░ now have a new ░░░░░░░░ of care So we ░░░░░░░░ have normally waited several ░░░░░░░░ until the day to ░░░░░░░░ the I and cross ░░░░░░░░ tea but the data ░░░░░░░░ not going to change ░░░░░░░░ of the numbers may ░░░░░░░░ a little but the ░░░░░░░░ will not change When ░░░░░░░░ was looking at this ░░░░░░░░ with our team the ░░░░░░░░ night it was reminiscent ░░░░░░░░ 34 years ago in ░░░░░░░░ when we were struggling ░░░░░░░░ drugs for HIV And ░░░░░░░░ had nothing There was ░░░░░░░░ lot of anecdotal reports ░░░░░░░░ things people were taking ░░░░░░░░ kinds of drugs We ░░░░░░░░ the first randomized placebo ░░░░░░░░ trial with AZT which ░░░░░░░░ out to give an ░░░░░░░░ that was modest But ░░░░░░░░ was not the end ░░░░░░░░ because building on that ░░░░░░░░ year after we did ░░░░░░░░ and better we had ░░░░░░░░ drugs of the same ░░░░░░░░ and we had drugs ░░░░░░░░ different targets This drug ░░░░░░░░ to be blocking an ░░░░░░░░ that the virus uses ░░░░░░░░ are a lot of ░░░░░░░░ enzymes that the virus ░░░░░░░░ that are now going ░░░░░░░░ be targets for this ░░░░░░░░ will be the standard ░░░░░░░░ care In fact when ░░░░░░░░ look at the other ░░░░░░░░ were doing we will ░░░░░░░░ a trial with another ░░░░░░░░ Actually it is in ░░░░░░░░ it s an anti ░░░░░░░░ We are going to ░░░░░░░░ compare the combination of ░░░░░░░░ with this So as ░░░░░░░░ come in we will ░░░░░░░░ if we can add ░░░░░░░░ that Bottom line you ░░░░░░░░ going to be hearing ░░░░░░░░ details about this This ░░░░░░░░ be submitted to a ░░░░░░░░ reviewed journal and will ░░░░░░░░ peer reviewed appropriately But ░░░░░░░░ think it s opening ░░░░░░░░ door to the fact ░░░░░░░░ we now have the ░░░░░░░░ of treating and I ░░░░░░░░ guarantee you as more ░░░░░░░░ more companies more investigators ░░░░░░░░ involved it s going ░░░░░░░░ get better and better ░░░░░░░░ will stop there but ░░░░░░░░ d be happy to ░░░░░░░░ any questions.”